There are several synonyms for the phrase "most know nothing". Some of these include: uninformed, ignorant, clueless, inexperienced, unaware, uneducated, naive, and simple-minded. These words all convey a similar meaning, and describe someone who lacks knowledge or understanding about a particular subject or situation. It is important to note that these words should be used with caution, as they can be seen as derogatory or insulting. Instead, it is often best to use more neutral language, such as "not well-versed in" or "lacking knowledge of". In any case, it is important to approach those who do not know much with patience and respect, as everyone has the potential to learn and grow.