The word "lenitive" means soothing or calming, so antonyms for "most lenitive" would describe words or actions that are harsh, abrasive, or jarring. Some antonyms for "most lenitive" might include disruptive, unsettling, agitating, rough, jarring, or abrasive. These words suggest that the opposite of a soothing or calming action is one that is difficult, unpleasant, or even painful. For example, instead of using a lenitive cream on an itchy rash, one might use a harsh astringent or scrubbing agent that would be the opposite of gentle and calming. Overall, antonyms for "most lenitive" suggest that anything that is not soothing could be considered the opposite of lenitive.