The words "nitty-gritty" are commonly used to describe the essential, most important details of a particular situation or topic. When looking for antonyms for this term, one could consider words that are the opposite of specific, detailed, or significant. Examples of such antonyms could include vague, superficial, trivial or inconsequential. Other potential antonyms for "nitty-gritty" could be related to the idea of being broad in scope or lacking detail, such as general or abstract. Overall, the antonyms for "most nitty-gritty" can vary depending on the context in which the word is being used, but generally they represent ideas that are the opposite of specific, detailed, or essential.