Antonyms for the word "most numbskulled" include intelligent, clever, astute, bright, sharp, smart, brilliant, knowledgeable, wise, and intuitive. These words describe individuals who possess high cognitive abilities and can think critically and solve complex problems easily. Unlike a numbskull, they are quick to grasp concepts and apply them to real-world situations. They are also known for their ability to make sound judgments and offer insightful perspectives on various issues. In contrast, a numbskull is generally characterized as someone who lacks intelligence and common sense, making foolish decisions and having difficulty understanding basic concepts.