The word "most numskulled" is a term used to describe someone who is extremely unintelligent or foolish. To find antonyms for this phrase, we need to look for words that describe intelligence, smartness or cleverness. Some antonyms for "most numskulled" could be "brilliant", "genius", "intelligent", "wise", "smart", "cunning", "shrewd", "astute", "clever" and "sagacious". They all convey the opposite meaning, and are used to describe someone who is exceptionally smart, able to solve complex problems, and displays great insight and understanding. These antonyms paint a more positive picture of intelligence, compared to the negative connotations of "most numskulled".