Most penny ante, meaning insignificant or small-scale, has several antonyms that represent a larger and more significant scope. The first antonym is substantial, indicating an ample, valuable, and weighty capacity, substance, or significance. Another antonym is colossal, representing something immense, enormous, or gigantic in size, influence or meaning. Majestic is another antonym, referring to something grand, magnificent, or impressive in appearance or scope. Moreover, the term significant is another antonym to most penny ante, indicating something meaningful, notable, or essential in value, impact, or influence. Overall, these antonyms of most penny ante connote a more abundant, meaningful, and impactful range, emphasizing their weight and worth on the scale of significance.