Most plugging can be characterized as the action of filling or blocking a hole, gap, or other opening. Antonyms for most plugging would include actions that are associated with creating openings, gaps, or holes. Words like unblocking, releasing, opening, freeing, and uncovering would all be considered antonyms to most plugging. For example, if you have blocked a drain, then unblocking it would be the antonym. In other cases, if you fill a gap, you can create an opening that would be the antonym. Having a good understanding of these antonyms can help you communicate more accurately and effectively in various scenarios where the word most plugging might be used.