Most runafter means the most popular or sought after. Opposite words for most runafter could be the least popular or ignored. Other antonyms could be unfashionable and unpopular. Words like unappealing, unattractive, and least favored are also antonyms for most runafter. Words such as unpopular, unloved, avoided, disregarded, and underappreciated also convey the opposite meaning of most runafter. These words are used to describe things, events, or people who are not desirable to the majority, and people tend to ignore them. Therefore, antonyms for most runafter may include unpopular, unfashionable, and least favored.