When we think of the word "most side-by-side," we often imagine two or more things closely juxtaposed. But sometimes, we need to describe a situation where things are not as close or near each other. In such instances, we can use antonyms to "most side-by-side."
Words like "apart," "distant," "separate," and "disconnected" are excellent antonyms for "most side-by-side." To illustrate, we can say that the two friends were sitting apart from each other, or the two buildings were separated by a significant distance. On the other hand, "most side-by-side" implies a proximity that antonyms would not convey. Therefore, when looking for an antonym for "most side-by-side," consider using words that suggest distance or separation between things.