The term "most trustless" can be understood as a lack of reliability or faith in someone or something. Conversely, antonyms for this word would include terms such as "most trustworthy," "most dependable," "most reliable," and "most credible." These words describe someone or something that can be trusted without question. Other antonyms for "most trustless" might include "most faithful," "most honest," and "most loyal." These words all suggest a sense of trust and faith that can be placed without concern for the outcome. Whatever the antonym used to describe the opposite of "most trustless," it is clear that trust and dependability are highly valued traits in any situation.