The phrase "most uncertainly" can be replaced with a variety of synonyms that convey a similar meaning of extreme doubt or uncertainty. Some possible options include "most doubtfully", "most hesitantly", "most tentatively", "most dubiously", "most skeptically", and "most indecisively". Each of these terms suggests a lack of confidence or clarity, and can be used in a variety of contexts such as discussing uncertain outcomes, expressing reluctance or skepticism, or conveying feelings of confusion and doubt. Ultimately, the choice of synonym will depend on the specific context and desired tone of the sentence or phrase in question.