The antonyms for the word "most uncheerful" are numerous and can vary depending on the context in which it is used. Some possible antonyms are "cheerful," "happy," "upbeat," "optimistic," "content," "joyful," and "merry." These words indicate a positive and cheerful outlook on life, contrasting with the pessimistic and gloomy connotations of "most uncheerful." Other antonyms might include "hopeful," "buoyant," "radiant," "positive," "enthusiastic," or "jubilant." Regardless of the specific choice of antonym, the words that oppose "most uncheerful" all suggest a way of being that is full of life, good humor, and positivity.