The antonyms for the word 'most unconsequential' are significant, meaningful, important, relevant, consequential, and momentous. These words signify the opposite meaning of the term 'most unconsequential,' which means not important, insignificant, and trivial. When we say something is significant, we mean it is essential, purposeful, and influential. Similarly, when we describe something as relevant, it is useful and pertinent enough to be taken into account. In contrast, the term most unconsequential bears a notion of unimportance, triviality, or irrelevance. Hence, it is essential to use appropriate antonyms to convey the right meaning and avoid confusion in communication.