Most fulfilled is the antonym for the word "most unfulfilled". It refers to the feeling of contentment, satisfaction, and achievement that one gains after accomplishing their goals and desires. When someone is most fulfilled, they feel complete and happy with their achievements, relationships, and personal growth. On the other hand, most unfulfilled means the opposite, which is the state of not having fulfilled or achieved one's goals or desires. It indicates a feeling of emptiness, dissatisfaction, and lack of purpose in life. Therefore, one should strive to achieve their goals and desires to live a fulfilled life.