The word "most unprofane" is often used to describe someone or something that is not irreverent or sacrilegious. Its antonyms, on the other hand, would describe people who are disrespectful, blasphemous, or profane. Some of the most common antonyms for "most unprofane" would include "irreverent," "sacrilegious," "blasphemous," "profane," "impious," "ungodly," and "sacrilegious." These words all represent a person or attitude that is the opposite of what is considered respectful, reverent or holy. By knowing the antonyms of "most unprofane," one can better understand the true definition and use of the word.