The word "most unprofaned" implies that something is pure or untainted, so the antonyms for this phrase could include impure, defiled, corrupted, or contaminated. Something that is unprofaned is untouched by negative or harmful influences, so antonyms for this concept might also include polluted, stained, tarnished, or spoiled. Depending on the context in which the phrase is used, other antonyms might be appropriate as well, such as dirty, adulterated, or damaged. Overall, antonyms for "most unprofaned" are words that convey the opposite idea of purity and suggest that something has been altered or degraded in some way.