The term "most uplifted" refers to someone who is extremely happy, joyful, or elevated in mood. The opposite of this would be someone who is dejected, sad, or low-spirited. Other possible antonyms for "most uplifted" could include words like disheartened, crestfallen, miserable, or depressed. Conversely, antonyms for "most uplifted" could also include words that denote a lack of intensity or enthusiasm, such as indifferent, unenthusiastic, or apathetic. Depending on the context in which the term "most uplifted" is being used, there may be several different antonyms that could accurately convey the opposite meaning.