The phrase "most upmost" means the highest or utmost level of something. It can be replaced by several synonyms such as ultimate, highest, topmost, paramount, supreme, foremost, or pinnacle. These words convey the idea of something being of the greatest importance or significance. For instance, a person could use "paramount" to describe the most upmost priority for a particular task. "Supreme" is another synonym that can be used to emphasize the importance of something. While "topmost" is a synonym that conveys the idea of being at the highest level, both physically and metaphorically. In summary, these synonyms for "most upmost" all express the idea of something being at the highest level possible.