The opposite of the phrase "most vindicatory" can be expressed using a variety of antonyms. Some of the most common antonyms for vindicatory include guilty, responsible, blameworthy, liable, or culpable. If a person or entity is deemed responsible for wrongdoing or has committed a crime, they cannot be considered vindicatory. Similarly, if somebody is not able to defend themselves effectively, or if their actions are found to be unjustifiable, they may be deemed culpable. Ultimately, the opposite of being "most vindicatory" is being found guilty or blameable, rather than innocent or justified.