The phrase "most well spent" signifies the efficient utilization of resources or time for a particular task or purpose. The antonyms for this phrase could include "poorly spent," "wasted," "squandered," "ineffectively utilized," and "misdirected." These words imply a negative aspect of the resources, indicating that they were not utilized efficiently or effectively for the desired result. When resources are squandered or misdirected, it often leads to undesirable outcomes, causing frustration or disappointment. It is, therefore, crucial to focus and plan appropriately to ensure that resources are best used and well-spent.