The phrase "most well-established" is used to describe something that is not only established but also considered the best or most successful in its field. Antonyms for this phrase could include unfamiliar, undeveloped, unexplored, unstable, untested, and experimental. These words suggest a level of uncertainty or lack of recognition, indicating that the thing in question is not yet fully accepted or proven. To describe something as "least well-established" would imply that it is struggling to gain traction, inexperienced, or simply not widely recognized. Therefore, it is important to carefully consider the context and intended meaning of this phrase when looking for suitable antonyms.