The phrase "most well-thought-of" refers to something that is held in high regard or esteemed. Antonyms for this phrase could be: disreputable, despised, reviled, notorious, infamous, or unrespected. These words connote a lack of esteem or prestige, and a negative perception of the subject. For example, a disreputable company would have a poor reputation and be viewed negatively by consumers. A despised individual would be shunned or disliked by others. Knowing the antonyms of "most well-thought-of" can help expand one's vocabulary and understanding of language nuances.