One-off is an idiom commonly used to describe a unique or one-time situation. There are a number of synonyms that can be used depending on the context of the situation. Some common synonyms for one-off include singular, exceptional, exclusive, unprecedented, and non-recurring. Other synonyms may include rare, infrequent, isolated, individual, and unique. Depending on the context of the situation, some of these synonyms may be more appropriate to use than others. For example, if describing a one-time opportunity, exclusive may be a better fit, while if describing a rare event, infrequent may be more appropriate. Regardless of the synonym used, each conveys the idea of something being unique and not likely to be repeated.