Over-familiar is a term that can be used to describe someone as excessively friendly or comfortable with another person. Some synonyms for this term might include intrusive, presumptuous, or overly intimate. These words suggest that someone is crossing a boundary or acting in a way that is inappropriate or unwelcome. Other words that could be used to describe this behavior might include pushy, overbearing, or nosy. In general, any term that suggests someone is being too forward or too familiar can be used to describe someone who is overstepping their bounds or making someone feel uncomfortable. It is important to remember that different people have different boundaries and thresholds for what they find acceptable, so it is always important to be aware of how your behavior might be perceived by others.