Over-familiarity refers to a situation where one becomes excessively familiar or informal with someone or something. The antonyms for this word are a few, and they include formality, caution, reserve, restraint, wariness, and distance. Formality implies behaving in a respectful manner as opposed to being too casual or too familiar. Caution, on the other hand, speaks to taking care and being careful not to cross any boundaries. Reserve suggests maintaining a standard level of professionalism and detachment in relationships. Restraint refers to controlling one's behavior and words, whereas wariness implies being alert to potential harm. Lastly, distance means keeping a healthy emotional and physical distance from people or situations.