Pantywaist is a derogatory term used to describe someone who is weak and timid. It is not an appropriate term to use in polite conversation, as it is considered offensive. There are several synonyms that can be used instead, such as meek, spineless, frail, feeble, timid, and cowardly. These words accurately describe someone who lacks courage or strength, without resorting to derogatory language. It is important to choose our words carefully, as they can have a powerful impact on those who hear them. Using more respectful language can help to create a more positive and inclusive environment for everyone.