Peutz-Jeghers Syndrome (PJS) is a rare genetic disorder characterized by the development of benign hamartomatous polyps in the digestive tract, as well as darkly pigmented spots on the lips, nose, mouth, and fingers. This condition is also known as hereditary gastrointestinal polyposis syndrome, and is caused by mutations in the STK11 tumor suppressor gene. Other synonyms for PJS includes Peutz-Jeghers polyposis syndrome, PJS syndrome, intestinal polyposis with mucocutaneous pigmentation, and periorificial lentiginosis with intestinal polyposis. While there is no cure for PJS, regular monitoring and screening can help prevent potential complications such as intestinal obstruction and cancer.