Plasminogen, also known as PLG, is a clot-dissolving enzyme that plays a vital role in fibrinolysis. Although plasminogen is the most commonly used term, there are several synonyms that can refer to the same molecule, such as PLGN, Glu-plasminogen, and Profibrinolysin. In some cases, these synonyms may refer to slightly modified forms of plasminogen that have different biological functions. For example, Glu-plasminogen has an additional glutamic acid residue at the N-terminal end that allows it to bind more strongly to fibrin. Understanding the various synonyms for plasminogen can aid in both research and clinical settings, as it ensures clear and accurate communication among scientists and healthcare professionals.