Powder-puff is a term generally used to describe something that is soft, delicate, and gentle. Therefore, antonyms for powder-puff would be words that represent something rough, tough, and sturdy. Opposite words of powder-puff might include words such as rough, abrasive, scratchy, tough, hard, strong, heavy, and rugged, among others. These words are often used to describe materials, surfaces, designs, or even people that are the complete opposite of powder-puff. While powder-puff might represent delicate beauty, the antonyms of the term represent a more rugged and tougher aspect, which can be just as attractive in certain situations.