Preantepenultimate is a complicated word that refers to the second-to-last item in a series. Synonyms for preantepenultimate include the words penultimate, antepenultimate, and prepenultimate. Penultimate is the most commonly used word to describe the second-to-last item in a series. Antepenultimate is another word with the same meaning, but it is a more elegant and formal word. Prepenultimate is another synonym that is rarely used but still means the same thing. Regardless of which word you use, the meaning remains the same and the word can be used to describe the second-to-last item in a series or sequence.