Re-run, as its name suggests, refers to a repetition of an action or event that has already occurred. However, it is not uncommon to come across situations where one may want to use a term that is opposite in meaning. In this case, the antonyms for re-run include words such as original, fresh, new, innovative, first, unique, and unconventional. These words convey a sense of novelty and creativity, as opposed to the repetitive nature of re-run. While re-runs can still be enjoyable, utilizing antonyms can help bring a sense of excitement and unpredictability to an experience.