Roberts syndrome, also known as Roberts-SC-phocomelia syndrome, is a rare genetic disorder that affects many parts of the body. It is caused by mutations in the ESCO2 gene, which provides instructions for making a protein that plays a critical role in the structure of chromosomes. The primary features of Roberts syndrome include growth delays, abnormal bone development, cleft lip and/or palate, and distinctive facial features. Other synonyms of Roberts syndrome include pseudothalidomide syndrome, SC-phocomelia syndrome, and split hand/split foot malformation with microcephaly. Management of this condition focuses on treating symptoms and supportive care, as there is no cure currently available.