Saint Ignatius' Itch is a term used to describe the strong urge to achieve greatness or make significant progress in life. It is a feeling that comes from a deep inner desire to do something bigger than oneself. There are several synonyms that can be used in place of Saint Ignatius' Itch. These include ambition, aspiration, desire, drive, motivation, passion, and determination. Each of these words speaks to the idea of striving for something that may seem unattainable or challenging, but that a person feels driven to pursue nonetheless. Whatever the term used, Saint Ignatius' Itch ultimately represents the pursuit of excellence in all areas of life.