Sandifer syndrome, sometimes referred to as Sandifer's disease, is a rare medical condition that affects infants and young children. It is characterized by spasms or jerking movements in the neck, shoulders, and head, which can be mistaken for seizures. These movements are often accompanied by acid reflux or gastroesophageal reflux disease (GERD). Although Sandifer syndrome is considered a rare condition, some synonyms may include GERD with neurological symptoms, infantile spasms with GERD, or infantile gastroesophageal reflux. Treatment for Sandifer syndrome typically involves managing GERD symptoms, such as medication or dietary changes, as well as addressing any underlying neurological conditions.