Sandhoff Disease, also known as GM2 gangliosidoses type 2, is a rare and fatal genetic disorder that affects the central nervous system. Synonyms for Sandhoff Disease include Tay-Sachs disease type 2, classical infantile GM2 gangliosidosis, and hexosaminidase A deficiency. The disease is caused by a mutation in the HEXB gene, which results in the accumulation of toxic substances in the nervous system, causing severe damage to the brain and spinal cord. Symptoms of Sandhoff Disease typically include muscle weakness, seizures, blindness, deafness, and intellectual disability. Unfortunately, there is currently no cure for Sandhoff Disease, and treatments are typically aimed at managing symptoms and improving quality of life.