SCID, abbreviated from Severe Combined Immunodeficiency, is a genetic disorder in which the immune system functions abnormally, leaving the affected person vulnerable to various infections. Synonyms for SCID include severe combined immunodeficiency disease, bubble boy disease, and boy in the bubble syndrome. The term 'bubble boy disease' arose due to the severe isolation required for sufferers, resembling the life of the boy portrayed in the 1976 film "The Boy in the Plastic Bubble." Other scientific terms used are neonatal thymic disorder, thymic alymphoplasia, and T-B- severe combined immunodeficiency. The exploration of SCID synonyms helps researchers, healthcare providers, and caregivers better understand and communicate the complex nature of the disorder.