The phrase "shakes on" refers to making a deal or agreement and is often associated with shaking hands to seal the agreement. Antonyms for this phrase could be words and phrases like disagree, refuse, disapprove, decline, repudiate, or balk. These words demonstrate a lack of agreement or refusal to come to an agreement. In business or personal interactions, it is important to clearly communicate agreements or disagreements to ensure mutual understanding. It is also important to understand the weight of the phrase "shakes on" and ensure that both parties are fully committed to the agreement before sealing it with a handshake.