The term "shifties" is an informal slang term that can have a variety of meanings depending on the context in which it is used. However, there are several synonyms that can be used in its place, depending on the intended meaning. For example, if referring to someone who is being sneaky or untrustworthy, synonyms might include "shifty," "sly," or "deceptive." On the other hand, if using the term to describe someone who is constantly changing their position or attitude, "fickle," "volatile," or "capricious" might be appropriate synonyms. Ultimately, the exact replacement for "shifties" will depend on the situation and intended connotation.