Sickle-cell anemia, also known as sickle cell disease, is a genetic blood disorder that affects the production of red blood cells in the body. This condition causes the cells to become shaped like a crescent or sickle, which can lead to numerous health complications. Some of the key synonyms for sickle-cell anemia include sickle cell disease, sickle cell disorder, sickle hemoglobinopathy, sickle cell trait, sickling disorder, and sickle erythrocytosis. While there is no cure for sickle-cell anemia, treatment options are available to help manage symptoms and prevent complications, including blood transfusions, medication, and bone marrow transplantation. Those with this condition can lead full and healthy lives with proper care and management.