Spondyloepimetaphyseal dysplasia (SEMD) is a rare genetic disorder that affects bone growth and development. The condition can cause a range of skeletal abnormalities, including deformities of the spine, hips, and long bones of the arms and legs. There are several different types of SEMD, each with its own set of symptoms and effects on the body. Synonyms for SEMD include spondyloepiphyseal dysplasia (SED), metaphyseal dysplasia, and dysspondyloepiphyseal dysplasia. While there is currently no cure for SEMD, treatment may involve physical therapy, surgery, and other supportive measures to improve the patient's quality of life.