Sprue is a condition that occurs when the small intestine fails to absorb nutrients properly. Some synonyms for the word sprue include celiac disease, gluten-sensitive enteropathy, and tropical sprue. These terms are often used interchangeably to refer to the same condition. Celiac disease is an autoimmune disorder that causes the body's immune system to attack the small intestine when gluten is consumed. Gluten-sensitive enteropathy is an umbrella term that refers to any condition in which the small intestine is damaged by gluten. Tropical sprue is a rare and severe form of malabsorption that occurs in people who have lived or traveled in tropical regions.