Synonyms for the St. Francis River, also known as the Saint Francis River, include the Saint Francois River, the Rio San Francisco, and San Francisco River. This 426-mile stretch of waterway flows through southeastern Missouri and northeastern Arkansas, providing a habitat for a diverse range of fish and wildlife. The river has long been an important resource for the local communities, supporting agriculture, industry, and recreation. From its beginnings in Iron County, Missouri, to its eventual convergence with the Mississippi River, the St. Francis River offers opportunities for boating, fishing, and outdoor adventure in the heart of the American Midwest.