There are many synonyms for the phrase "suffering misfortune." One could say that someone is experiencing hardship, adversity, difficulty, or affliction. They could also be going through a crisis, a setback, a tragedy, or a rough patch. Other possible synonyms include distress, sorrow, pain, and agony. It's important to note that while these words may be interchangeable to some extent, they can also convey slightly different connotations or nuances. For instance, hardship may imply a struggle or challenge that is difficult but potentially temporary, while tragedy may suggest a more permanent loss or hardship. In any case, there are many ways to describe the experience of struggling through difficult times.