Owing to the inability to eat and to the general systemic disturbance present, the animal loses flesh very rapidly and becomes greatly emaciated in the latter stages of the disease.
"Special Report on Diseases of Cattle"
U.S. Department of Agriculture J.R. Mohler
Now the thought evolved to hasten the work of systemic cleansing, begun with denial.
"She Buildeth Her House"
Will Comfort
But when Servetus comes to speak of the systemic circulation, what he has to say is as old as Galen.
"Fathers of Biology"
Charles McRae