The phrase "take a hand" can have different synonyms depending on the context. For instance, in a card game, it could mean "deal" or "shuffle." In a physical sense, it could mean "hold" or "grip." In a figurative sense, it could mean "manage" or "guide." Additionally, "take a hand" could also signify being involved or participating in something, which could be substituted with "join in," "engage," or "take part." It's important to consider the context and the intended meaning of the phrase when looking for synonyms, as they can vary greatly.