When it comes to taking risks, the phrase "take one's life in one's hands" is commonly used. However, there are several other synonyms that can be used instead of this phrase, depending on the context. Some of these synonyms include "court danger," "live dangerously," "face the unknown," "brave uncertainty," "gamble with one's life," "embrace risk," "challenge fate," and "tempt fate." Each of these phrases can be used to describe situations where someone is knowingly putting themselves in danger or taking a chance in a potentially risky situation. As with any phrase or saying, it's important to choose the right synonym that fits the context of the situation.