There are numerous synonyms for the phrase "takes charge of" which means to become responsible for overseeing a situation or project. Some alternatives include assumes control, assumes leadership, leads, directs, manages, supervises, oversees, guides, heads, governs, controls, dominates, commands, spearheads, and takes the reins. These synonyms are useful when trying to convey a particular tone or style. For example, "assumes control" suggests a more authoritative approach, while "guides" implies a more collaborative one. By using synonyms, you can add nuance and precision to your writing, creating a more nuanced and effective message.