Taking a shot at something, commonly used as a phrase to indicate an attempt, has a few antonyms that can convey the opposite meaning. The antonyms for taking a shot at include avoiding, shirking, evading, and neglecting. These antonyms describe a sense of hesitancy or disinterest in trying or attempting something. Alternatively, synonyms like giving it a go, making an effort, or taking a stab at, can be used to indicate a proactive and enthusiastic approach towards a task or activity. Using the right antonym or synonym to describe a situation can help in clear communication and avoid any confusion or misinterpretation.