The phrase "taking up with" typically implies forming a relationship with someone or something, but what about when we want to express the opposite? In other words, when we want to convey the idea of distancing oneself from a person or situation, we can use antonyms like "breaking up with," "moving away from," "disengaging from," "cutting ties with," or "letting go of." Each of these phrases conveys the sense of ending a connection, withdrawing from an unhealthy or unwanted relationship, or simply ceasing to be involved with something that does not serve us well.