Throwing one's lot with means to align oneself with someone or something, often in a risky or uncertain situation. The antonyms for this phrase would be to dissociate, to distance oneself, to disengage, or to disentangle. When someone does not want to involve themselves with a particular person or group, they may choose to withdraw, disavow, or disconnect from them. Alternatively, they could choose to stand alone or remain neutral instead of aligning themselves with a specific person, group or cause. Throwing one's lot with may seem appealing in some situations, but it is also important to consider the associated risks and consequences before committing oneself to any particular course of action.